Raydrop Double Emulsions

[ORDRPDE]

    Double emulsion droplets & microcapsules generator

    The RayDrop is a microfluidic droplet generator composed of three main parts fully removable: two inserts on each side and a center section containing a nozzle and an outlet capillary. There are four standard microfluidic connections, two on the box for the continuous phase, and one on each insert for the dispersed phase entry and the collecting emulsion outlet.

    The RayDrop specific design allows for multiple liquid type emulsification, within the same device without any coating needed. This allows to cover single and complex emulsion such as Double emulsion.

    Main benefits
    • droplet monodispersity
      Reproducible

      High monodispersity (CV < 2%)

    • Flexible

      Multiple applications

    • Easy

      One device, coating-free

    Features

    A flexible device

    Droplet size from 50 µm to 140 µm outer diameter. Frequency of up to 5 000 Hz. Water-in-oil-in-water (w/o/w) and oil-in-water-in-oil (o/w/o).

    A unique device

    Perform double emulsions in one single device.

    Surface coating-free

    As opposed to standard double emulsion devices, the Raydrop does not require any surface coating steps.

    Easy to use

    Easy-to-clean exchangeable nozzle. Easy microscope visualization.

    Developed and manufactured by Secoya

    Description

    The RayDrop specific design allows for multiple liquid type emulsification, within the same device without any coating needed. This allows to cover complex emulsion such as Double emulsion.

    This allows to cover many application from encapsulation of active pharmaceutical ingredient or cell and fragrance encapsulation in polymer microcapsules.

    The RayDrop Double emulsion is available in a standard configuration (Core Nozzle size-Shell Nozzle size-Extraction capillary size):

    30 µm – 70 µm – 150µm

    As all cappilaries from the RayDrop are easily excheangable it’s easy to change either the nozzle capillary or the collecting cappilary with another nozzle or cappilary size.


    It can also be tuned to target different droplet size by changing cappialries size and nozzle configuration:

    Small droplet configuration: 30µm-70µm-90µm

    This two nozzle configuration allow to decrease double emulsion size down to 50 µm double emulsion size.

    Specifications

    Device characteristicsCo-Flow focusing design
    Droplet typewater in oil in water and oil in water in oil
    Double emulsion sizeShell: 50 to 140 µm
    Core: 20 to 120 µm
    Generation rate5 000 Hz (measured for the smallest double emulsion size) – can go higher under specific conditions
    Nozzle typeMethalcrylate resin
    Nozzle sizeCore: 30 µm ID
    Shell: 70 µm ID
    Inlet and outlet capillary150 µm ID
    External dimensionsL*l*h = 92,5 mm * 52 mm * 13,5 mm
    Weight405
    Operating pressure0 – 5 bar
    Burst pressure10 bar
    Wetted material: continuous phasePEEK, FEP, glass, stainless steel, polyimide, Kalrez (seal), methalcrylate resin or glass (nozzle)
    Wetted laterial: dispersed phase PEEK, FEP, glass, methalcrylate resin or glass (nozzle)

    PNProduct nameCapillary sizesNozzle type
    ORDRPDE-30-70-150Complete Raydrop30µm-70µm-150µmMethacrylate Resin
    O-DE-RDRPC04-EUPComplete Raydrop30µm-70µm-90µmMethacrylate Resin
    O-SP-DNI3070-CODouble nozzle insert30µm-70µmMethacrylate Resin
    ORDRPSNO-90Simple nozzle insert90µmMethalcrylate resin
    ORDRPSNO-60Simple nozzle insert60µmMethacrylate Resin
    ORDRPCOL-150Collecting capillary insert150µmGlass

    Double emulsion production: Raydrop method


    How to fill the Raydrop?

    Which solvent is compatible with the Raydrop?

    As chemicals, can be used ethylacetate, ethanol or IPA. (The nozzle material is not compatible at long-term use with dichloromethane)


    Do I need to filter my solutions?

    Yes, we recommend filtering all solutions before starting your experiment. The presence of dust can block the nozzle.


    There is an air bubble in my device. How can I get rid of it?

    Open the top plugs of the RayDrop.

    Return to the RayDrop filling state.

    Refer to the application note protocol.


    There is a fluid leak coming our from the sides of the Raydrop. Is it a common behavior?

    Leaks can sometimes appear if the fluidic connectors are not tightened enough.

    Check that all the connectors are attached firmly.

    (Be careful not to over tighten or your tubing may be blocked by pinching)


    All my connectors are tigh but there is still water flowing out of the Raydrop window. Is this a common behavior?

    If the RayDrop has been manipulated (for cleaning or maintenance) the four screws might not be tightened enough.

    Use an allen key to tighten.


    How do I clean the Raydrop after my experiment?

    It is important to clean the RayDrop after each experiment in order to prevent clogging.

    Refer to the good practice guide for the detailed procedure.


    How can I avoid air bubble infiltration?

    Make sure that all tubing is well flushed before connecting the RayDrop.