Double emulsion for the generation of microcapsules - a Review
In this white paper, we synthetized the production of microcapsules of various materials ranging between 40µm and 250µm. The microfluidic system is described below, along with the chemicals used and the optimal concentrations.
Using droplet-based microfluidics as a method for generating microcapsules is of growing interest in the scientific community, as it offers great potential in delivering active pharmaceuticals ingredients (APIs). The molecule can be encapsulated in the core of the droplets, surrounded by a protective shell that enables the transport of the drug to specific locations of the body, while eliminating, unwanted secondary effects and collateral damages.
While conventional bulk methods for the generation of microcapsules are limited by droplet polydispersity and high reagent loss, microfluidics offers a way to produce highly-monodisperse double emulsions with a higher encapsulation efficiency. Here, we present different ways to generate double emulsions for microcapsule production using the complex emulsion platform, developed by Secoya and equipped with our pressure-based flow control technology.
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TABLE OF CONTENTS
a. The Raydrop
b. Microfluidic double emulsion platform
IV. Use case 1: Chitosan microcapsules
V. Use case 2: Agarose microcapsules
VI. Use case 3: Alginate microcapsules
VII. Use case 4: PLGA microcapsules
VIII. Use case 5: Polymethacrylate resins microcapsules
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