Double emulsion for the generation of microcapsules - a Review​

In this white paper, we synthetized the production of microcapsules of various materials ranging between 40µm and 250µm. The microfluidic system is described below, along with the chemicals used and the optimal concentrations.

Using droplet-based microfluidics as a method for generating microcapsules is of growing interest in the scientific community, as it offers great potential in delivering active pharmaceuticals ingredients (APIs). The molecule can be encapsulated in the core of the droplets, surrounded by a protective shell that enables the transport of the drug to specific locations of the body, while eliminating, unwanted secondary effects and collateral damages. 

While conventional bulk methods for the generation of microcapsules are limited by droplet polydispersity and high reagent loss, microfluidics offers a way to produce highly-monodisperse double emulsions with a higher encapsulation efficiency. Here, we present different ways to generate double emulsions for microcapsule production using the complex emulsion platform, developed by Secoya and equipped with our pressure-based flow control technology

white paper generation of microcapsules

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I. Terminology 

II. Introduction 

III. Equipment 

a. The Raydrop 

b. Microfluidic double emulsion platform 

IV. Use case 1: Chitosan microcapsules 

V. Use case 2: Agarose microcapsules 

VI. Use case 3: Alginate microcapsules 

VII. Use case 4: PLGA microcapsules 

VIII. Use case 5: Polymethacrylate resins microcapsules 


Related Ressources

Agarose microcapsules synthesis 

Alginate microcapsules synthesis 

Encapsulation of multiple emulsions in a single droplet 

Double emulsion generation 

Microfluidic chitosan microcapsules production 

PLGA microcapsules synthesis 

UV-Crosslinking of microcapsules 

Other white papers 

Droplet-based microfluidics 

A guide to organ-on-chips terminology 

An exploration of microfluidic technology and fluid handling 

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