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PLGA Microparticle Production Standard Pack 

[1DPPL01]

    Produce monodispersed PLGA microparticles

    The PLGA microparticle production station is a robust, high-performance solution for generating polymer microparticles in a homogenous and fully controlled manner. The performance provided by the RayDrop droplet generator, together with the combination of poly(lactic-co-glycolic acid) as an encapsulation polymer and ethyl acetate as a solvent, offers a biocompatible solution lowering both hazard risk and precipitation time. Suitable for biological applications, the RayDrop and its station offer a semi-automated solution for one of the most successful drug delivery systems used in laboratories and clinics. Droplet based microfluidics shows potential as a powerful tool in solving the current problems of PLGA microparticle synthesis. Droplet control and generation allows for highly monodisperse, stable and continuous production as compared to batch emulsion methods.

    The PLGA Microparticle Production Standard Pack offers the option to generate PLGA microparticles manually by using the potential of the RayDrop device and the fluid control precision and stability of Fluigent instruments.

    Ask for a quote
    Main benefits
    • droplet monodispersity
      Repeatability

      High monodispersity (2%)

    • Flexibility

      Control over particle size

    • ease-of-use-website
      Ease of use

      Straight forward set up

    Features

    A complete system

    With the PLGA pack, you have all the components needed to start generating PLGA microparticles 

    An engineered solution

    We built the package with the right pressure controllers, microfluidic chips, and valves to give you maximum flexibility in terms of droplet size and generation rate 

    A dedicated protocol

    A protocol is available to assist you in setting up and starting your experiments 

    Customization possible

    We can adapt the PLGA Microparticle production standard pack to meet your needs (droplet size, generation rate, double emulsion) 

    Related applications

    • Microfluidics for Droplet Generation

      Discover
    Raydrop Double Emulsion Device

    Microfluidic Double Emulsion Device

    Microfluidic Double Emulsion Device

    Read more

    Developed and manufactured by Secoya

    Logo-Secoya

    Main products of the package

    • Raydrop Single Emulsion Chip Secoya Fluigent

      Microfluidic Single Emulsion Device

      Microfluidic single emulsion device

    • Flow EZ™ microfluidic flow controller

      Microfluidic flow controller

      Microfluidic flow controller

    • FLOW UNIT microfluidic flow sensor

      Bidirectional Microfluidic Flow Sensor

      Bidirectional Microfluidic Flow Sensor

    • Airtight metal tube caps for microfluidics

      P-CAP series

    • LINK Microfluidic Software control

      Microfluidic Software Control 

      Microfluidic Software control

    • Real-Time Control & Automation Software

      Real-time control and Automation software

    droplet generation plga
    drug encapsulation webinar

    Specifications

    PLGA PARTICLE PRODUCTION

    Dispersed phasePLGA lactide: glycolide (75:25), mol wt 66,000-107,000
    PLGA concentration used2%, 5% ans 10%
    Continuous phaseEthyl acetate
    Doplet size range60µm to 120 µm
    Particle size range20µm to 50 µm
    Production rateUp to 60mg/h
    Production frequencyU to 1000Hz
    Monodisperity2%

    FLOW CONTROL

    PumpsFluigent Flow EZ™ (2000mbar)
    Flow sensorsFluigent FLOW UNIT (M and L)
    Automated valvesFluigent 2-SWITCH™

    IMAGING

    MicroscopeFluigent Digital high-speed microscope

    OxyGEN

    Control in real-time, protocol automation, data record and export
    ver. 2.2.0.0 or more recent

    See the offer


    Imaging

    Pixelike Capture Software

    Traditional methods (Batch methods)Fluigent PLGA microparticle production station
    Particle size distribution~20%~2%
    ReproducibilityLowHigh
    API mixingUnevenUniform
    Live particle size controlNoPrecise
    Continuous / In line production NoYes
    Microfluidic methods available on the marketFluigent PLGA microparticle production station
    Particle size distribution~5%~2%
    Semi automated productionNoYes
    Ethyl acetate dedicated protocolNoYes
    Device regenerationNo (glass chip changed when clogged)Yes (the RayDrop can be maintained)
    ConnectorsNon standard, user dependant quality (leakage, blockage)Standard fittings for better sealing

    Can I use a polymer other than PLGA?

    The method has been designed for PLGA. Changing polymers may change the physical fluid properties and lead to different results.

    PLGA-molecule

    How can I prevent the clogging from PLGA?

    Follow the procedure detailed in the application note. Please note the priming and cleaning procedures.

    The nozzle (or capillary) sems clogged with PLGA. How can I fix it?

    If the usual cleaning procedures from the good practice guide cannot unclog the nozzle, contact customer support for help.

    Some of the ethyl acetate has flowed into the continuous phase chamber. What should I do?

    If some ethylacetate without PLGA has flowed into the chamber it can be flushed out easily.

    Follow the instructions in the good practice guide.

    I can see a drop of ethlacetate fixed on the outside of the nozzle. How can I get ride of it?

    If some ethylacetate  without PLGA is fixed around the nozzle, it can be easily flushed out.

    Follow the instructions in the good practice guide.

    Some of the PLGA solution has flowed into the chamber. What shoulg I do?

    If some PLGA gets into the chamber, it has to be eliminated quickly.

    Refer to the good practice guide for the exact procedure.

    Air bubbles regularly appear during the experiment. What should I do?

    If air bubbles appear during experiment we advise one to switch to the ethyl acetate solution (if you are in the PLGA configuration) and let it flow for a minute to remove all PLGA from the system.

    Then make sure that all connectors are tightened properly.

    Refer to the application note procedure to avoid air bubble infiltration.

    Expertise & resources

    • Microfluidics White Papers Double emulsion for the generation of microcapsules – a Review​ Read more
    • Fluigent products manual Good practice guide PLGA station Download
    • Microfluidics White Papers Droplet-based Microfluidics Read more
    • Fluigent Products Datasheets PLGA Microparticle production station Datasheet Download
    • Microfluidic Webinars Drug encapsulation in biocompatible microparticles for drug delivery Read more
    • Microfluidic Webinars Raydrop, a universal droplet generator based on a non-embedded co-flow-focusing Read more
    • Fluigent Products Datasheets Raydrop single emulsion datasheet Download
    • Expert Reviews: Basics of Microfluidics The Raydrop | A new droplet generation device based on non-embedded co-flow-focusing Read more
    • Microfluidic Application Notes PLGA Microparticles Synthesis Read more
    • Fluigent Products Datasheets FLOW UNIT Datasheet Download
    • Expert Reviews: Basics of Microfluidics Microfluidic chips: key applications Read more
    • Fluigent Products Datasheets Flow EZ™ Datasheet Download

    Related products

    • PLGA Microparticle Production Pack (Automation Pack)

      PLGA Microparticle Production Pack (Automation Pack)

      See the offer

    Accessories

    • Microfluidic Low Pressure Generator

      Discover
    • Pressurized fluid reservoirs

      Microfluidic Pressurized Fluid Reservoirs

      Discover

    Kits

    • PLGA station tubing & fitting kit

      Buy online
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