Omi, automated organ-on-chip platform

[O-OMISC-PTF]

New release

A one-of-a-kind innovative Organ-on-Chip Platform

Omi is an automated platform that helps reproduce the microphysiological behavior of organs inside microfluidic chips. It is compatible any type of chips to sustain different cell culture types or organ on chip models (Liver, Gut, Skin…)

Ask for a quote Specifications

Omi organ-on-a-chip platform for micro physiology experiment and cell culture

Main benefits

Designed for biology
Suited for cell culture under sterile conditions
Versatile
Can be used with any microfluidic chip design
Efficient
Automated and fully integrated platform
Easy-to-use
Intuitive interface and technology for beginners and advanced researchers

Step up your organ on chip game!

If you’re performing organ-on-a-chip or 3D cell culture experiments, and want a simple setup for automated medium perfusion and recirculation that will fit in an incubator and be compatible with microscopy imaging?

Watch our webinar recording

Features of the cell culture platform

Fully integrated platform

Omi can perform user customized protocol including perfusion, recirculation, injection and sampling.

Compact and transportable

The device is designed to fit in incubators and can be easily transported to a microscope for imaging or cell analysis while maintaining perfusion.

Remote control

Set up and monitor your protocols on Omi’s application’s user friendly interface with WIFI.

Contamination-free

Inject cell or fresh medium, deliver test compounds, collect samples without disconnecting the microfluidic chip and disturbing the shear stress conditions of the experiments.

Completely autonomous platform

2-hour battery allows for transport from incubator to imaging system.

Related applications

Control your experiments with Fluigent’s Omi

Omi, automated organ-on-chip platform, can perform any perfusion protocol. It has the ability to customize and automate any protocol that includes simple perfusion, recirculation, sampling and injection. It meets the needs of both beginners in cell culture research and advanced Organ-on-Chip researchers who seek automation and reproducibility.

Designed to fit in incubators, and easy to transport to a microscope for imaging or cell analysis.

This versatile and automated organ-on-chip platform can perform long term cell culture under flow to control shear stress conditions. Its two-hour autonomy battery and Wifi connectivity ensure easy and intuitive monitoring. It can easily be transported from an incubator to a microscope to perform live cell imaging while maintaining cell perfusion under battery power.

omi fluigent Reproducibility and experiment duplication

Reproducibility and experiment duplication have never been this easy!

Omi can be used in different modes :

Single mode : signel channel perfusion for cell culture, such as blood vessel reproduction

Dual mode : double channel perfusion for co culture to perform liquid/liquid interface or blood brain barrier reproduction by synchronizing two Omi with one organ-on-chip .

One incubator, several Omis

This space saving platform allows multiple Omis (in dual or single mode) inside a single incubator to reproduce a given experiment. Units can then be easily transported to a microscope for real-time monitoring.

A range of protocol functions possible with a single Organ-on-Chip Platform

Perfusion

Perfuse up to 4 mL of several types of liquids such as cell culture media for a long period of time in a controlled and reproducible way. The stability and precision of the perfusion allow control of the shear stress throughout any experiment.

Recirculation

Unidirectional recirculation of medium while maintaining a constant flow rate for a long period of time. Read our technical note on long term recirculation for organ on chip applications.

Sampling

Sample up to 4 mL of soluble factors secreted in the culture medium for analysis or imaging.

Injection

Inject up to 4 mL of fresh medium during the experiments.

Applications

Omi is the perfect automated organ-on-chip platform for any organ-on-a-chip application. It allows the simulation of any organ
model, and by pairing several Omi together, one can model different interfaces for modeling of human organs.

The Omi is ideal for drug discovery, ADME-Tox, and other disease models.

Discover more about Organ-on-chip technology and its diverse applications with our white paper

Single Channel Configuration

Blood Vessel Reproduction

Study drug transport or nutrient absorption with endothelial cells-on-chip with Omi.

Cancer Drug Discovery

Mimic the effect of drug compounds on tumor cells to evaluate their response to the treatments.

Double Channel Configuration

Liquid / Liquid interface

Omi’s fluidic system allows, when paired in 2, to model liquid-liquid interfaces to reproduce
physiological functions of different human organs.

Blood-brain-Barrier

Assess vascular permeability using our platform and brain cells-on-chip. Our microfluidic functionalities and protocols allow for accurate cell organization and physiology to study the microenvironment of the human brain.

Gut-on-chip

Study drug absorption and interaction with endothelial cells in gut-on-chip models with Omi’s fluidic functionalities. Inject new nutrients or drugs and analyze cell behavior by sampling the medium.

Read the application note

Read the technical note on long term recirculation

Specifications

PERFORMANCE

Flow rate control	From 1 µL/min to 1 mL/min
Maximum pressure	800 mbar at maximum
Fluid reservoir volume	4 mL
Perfusion volume	From 1.5 mL to 4 mL
Min volume recirculated	2,5 mL

HARDWARE SPECIFICATIONS

*Dimensions (LWH)*	190 x 120 x 60 (mm)
Weight	757 g
Operating temperature	15-40°C
Gas input pressure	Atmospheric pressure
Gas input composition	Dry 2 µm-filtered ait, nitrogen

ELECTRONICAL SPECIFICATIONS

Power supply voltage	24 V DC
Max energy consumption	12 W
Max current requirement	0.5 A
Battery autonomy	2 h

CARTRIDGE SPECIFICATIONS

Dimensions	80 x 60 x 36 (mm)
Weight	56 g
Materials	Medical grade polycarbonate and MVQ silicone*
Working fluids	Water based solutions, IPA, Ethanol
Cleaning	Isopropanol, 80%/20% v/v water ethanol solution

*Check the material compatibility of the used solutions with the wetted materials

TUBING SPECIFICATIONS

Material	FEP (provided) , but other materials possible depending on the connector
ID	250 μm (provided), but other can be used depending on the application
OD	1/16” (provided), but other can be used with a compatible 1⁄4-28 flat bottom connector

Omi SOFTWARE (tablet)

Control in real-time, protocol automation, data record and export

ver. 1.0.0.0 or more recent

*Provided with the Omi device

https://play.google.com/store/apps/ details?id=com.fluigent.omi&pli=1

Omi WEB

https://omi.fluigent.com/login