Suited for cell culture under sterile conditions
Omi, automated organ-on-chip platform
[O-OMISC-PTF]- New release
A one-of-a-kind innovative Organ-on-Chip Platform
Omi is an automated platform that helps reproduce the microphysiological behavior of organs inside microfluidic chips. It is compatible any type of chips to sustain different cell culture types or organ on chip models (Liver, Gut, Skin…)
- Designed for biology
- Versatile
Can be used with any microfluidic chip design
- Efficient
Automated and fully integrated platform
- Easy-to-use
Intuitive interface and technology for beginners and advanced researchers
Step up your organ on chip game!
If you’re performing organ-on-a-chip or 3D cell culture experiments, and want a simple setup for automated medium perfusion and recirculation that will fit in an incubator and be compatible with microscopy imaging?
Features of the cell culture platform
Fully integrated platform
Omi can perform user customized protocol including perfusion, recirculation, injection and sampling.
Compact and transportable
The device is designed to fit in incubators and can be easily transported to a microscope for imaging or cell analysis while maintaining perfusion.
Remote control
Set up and monitor your protocols on Omi’s application’s user friendly interface with WIFI.
Contamination-free
Inject cell or fresh medium, deliver test compounds, collect samples without disconnecting the microfluidic chip and disturbing the shear stress conditions of the experiments.
Completely autonomous platform
2-hour battery allows for transport from incubator to imaging system.
Control your experiments with Fluigent’s Omi
Omi, automated organ-on-chip platform, can perform any perfusion protocol. It has the ability to customize and automate any protocol that includes simple perfusion, recirculation, sampling and injection. It meets the needs of both beginners in cell culture research and advanced Organ-on-Chip researchers who seek automation and reproducibility.
Designed to fit in incubators, and easy to transport to a microscope for imaging or cell analysis.
This versatile and automated organ-on-chip platform can perform long term cell culture under flow to control shear stress conditions. Its two-hour autonomy battery and Wifi connectivity ensure easy and intuitive monitoring. It can easily be transported from an incubator to a microscope to perform live cell imaging while maintaining cell perfusion under battery power.
Reproducibility and experiment duplication have never been this easy!
Omi can be used in different modes :
Single mode : signel channel perfusion for cell culture, such as blood vessel reproduction
Dual mode : double channel perfusion for co culture to perform liquid/liquid interface or blood brain barrier reproduction by synchronizing two Omi with one organ-on-chip .
One incubator, several Omis
This space saving platform allows multiple Omis (in dual or single mode) inside a single incubator to reproduce a given experiment. Units can then be easily transported to a microscope for real-time monitoring.
A range of protocol functions possible with a single Organ-on-Chip Platform
Perfusion
Perfuse up to 4 mL of several types of liquids such as cell culture media for a long period of time in a controlled and reproducible way. The stability and precision of the perfusion allow control of the shear stress throughout any experiment.
Recirculation
Unidirectional recirculation of medium while maintaining a constant flow rate for a long period of time. Read our technical note on long term recirculation for organ on chip applications.
Sampling
Sample up to 4 mL of soluble factors secreted in the culture medium for analysis or imaging.
Injection
Inject up to 4 mL of fresh medium during the experiments.
Applications
Omi is the perfect automated organ-on-chip platform for any organ-on-a-chip application. It allows the simulation of any organ
model, and by pairing several Omi together, one can model different interfaces for modeling of human organs.
The Omi is ideal for drug discovery, ADME-Tox, and other disease models.
Discover more about Organ-on-chip technology and its diverse applications with our white paper
Single Channel Configuration
Blood Vessel Reproduction
Study drug transport or nutrient absorption with endothelial cells-on-chip with Omi.
Cancer Drug Discovery
Mimic the effect of drug compounds on tumor cells to evaluate their response to the treatments.
Double Channel Configuration
Liquid / Liquid interface
Omi’s fluidic system allows, when paired in 2, to model liquid-liquid interfaces to reproduce
physiological functions of different human organs.
Blood-brain-Barrier
Assess vascular permeability using our platform and brain cells-on-chip. Our microfluidic functionalities and protocols allow for accurate cell organization and physiology to study the microenvironment of the human brain.
Gut-on-chip
Study drug absorption and interaction with endothelial cells in gut-on-chip models with Omi’s fluidic functionalities. Inject new nutrients or drugs and analyze cell behavior by sampling the medium.
Specifications
PERFORMANCE
Flow rate control | From 1 µL/min to 1 mL/min |
Maximum pressure | 800 mbar at maximum |
Fluid reservoir volume | 4 mL |
Perfusion volume | From 1.5 mL to 4 mL |
Min volume recirculated | 2,5 mL |
HARDWARE SPECIFICATIONS
Dimensions (L*W*H) | 190 x 120 x 60 (mm) |
Weight | 757 g |
Operating temperature | 15-40°C |
Gas input pressure | Atmospheric pressure |
Gas input composition | Dry 2 µm-filtered ait, nitrogen |
ELECTRONICAL SPECIFICATIONS
Power supply voltage | 24 V DC |
Max energy consumption | 12 W |
Max current requirement | 0.5 A |
Battery autonomy | 2 h |
CARTRIDGE SPECIFICATIONS
Dimensions | 80 x 60 x 36 (mm) |
Weight | 56 g |
Materials | Medical grade polycarbonate and MVQ silicone* |
Working fluids | Water based solutions, IPA, Ethanol |
Cleaning | Isopropanol, 80%/20% v/v water ethanol solution |
*Check the material compatibility of the used solutions with the wetted materials
TUBING SPECIFICATIONS
Material | FEP (provided) , but other materials possible depending on the connector |
ID | 250 μm (provided), but other can be used depending on the application |
OD | 1/16” (provided), but other can be used with a compatible 1⁄4-28 flat bottom connector |
Omi SOFTWARE (tablet)
Control in real-time, protocol automation, data record and export |
ver. 1.0.0.0 or more recent |
*Provided with the Omi device
https://play.google.com/store/apps/ details?id=com.fluigent.omi&pli=1
Omi WEB
Expertise & resources
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Microfluidic Application Notes Long-term fluid recirculation system for Organ-on-a-Chip applications Read more
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Microfluidics case studies CNRS/UTC: study of a liver-on-a-chip model Read more
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User manuals Omi Fluigent User Manual Download
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Technical datasheets Omi Fluigent Technical Datasheet Download
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Expert Reviews: Basics of Microfluidics Why is a controlled shear-stress a key parameter of your microfluidic experiments? Read more
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Expert Reviews: Basics of Microfluidics Key considerations for fluidic system integration Read more
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Microfluidic Application Notes Peristaltic Pump vs Pressure-Based Microfluidic Flow Control for Organ on Chip applications Read more
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Expert Reviews: Basics of Microfluidics Mimicking in-vivo environments: biochemical and biomechanical stimulation Read more
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References
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