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Droplet generator

The RayDrop is a microfluidic droplet generator composed of three main parts fully removable: two inserts on each side and a center section containing a nozzle and an outlet capillary. There are four standard microfluidic connections, two on the box for the continuous phase, and one on each insert for the dispersed phase entry and the mixed phase or droplets exit.

The RayDrop works as a co-flow focusing principle. The nozzle and outlet capillary are aligned in continuous phase chamber, the dispersed phase comes through the nozzle to create the microparticles into the continuous phase and exit by the outlet insert.



Continuous production

Droplet size

40 µm to 130 µm

Exchangeable nozzle

Ease of use

Body warranty

Droplet frequency

up to 10 000 Hz

Standard connections

Droplet generation

no coating/surfactant needed


PLGA microparticle synthesis

PLGA encapsulation using raydrop droplet generator nozzle zoom



oil in water droplets generation with raydrop


water in oil droplet generation using raydrop device

Methacrylate resin-in-Water

Ethyl acetate-in-Water

Ethyl acetate in water droplet generation with raydrop device

PLGA microparticles

PLGA microparticles generated with raydrop and observed with high-speed camera


Inlet and outlet capillaries: 150µm ID

Nozzle: 30µm ID

Dimensions: L *w * h = 60mm * 40mm * 13 mm

Weight: 205 g

Part Number: 1DPRD01

RayDrop droplet generator with standard microfluidic fittings


“My team has started using the Fluigent microfluidic kit for making polymer based particles. We tried different microfluidic systems in the past but unfortunately they were not suitable for our application. The main issue was chip blockage which rendered the process quite laborious.

The RayDrop microfluidic chip from Fluigent gave us the best results with a better control over the process.

I have to mention the excellent technical support from Fluigent, their team visited my lab 3 times to deliver training and help to optimize the process”


Senior Lecturer in Pharmaceutics

Health and Life Sciences

De Montfort University , The Gateway, Leicester

icon questions


As chemicals, can be used ethylacetate, ethanol or IPA. (The nozzle material is not compatible at long-term use with dichloromethane)


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Ethyl acetate molecule
icon green tick
Ethanol molecule
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IPA molecule
icon red cross
Dichloromethane molecule

Ethyl acetate




Yes, we recommend filtering all solutions before starting your experiment. The presence of dust can block the nozzle.

Open the top plugs of the RayDrop.

Return to the RayDrop filling state.

Refer to the application note protocol.

Leaks can sometimes appear if the fluidic connectors are not tightened enough.






Check that all the connectors are attached firmly.







(Be careful not to over tighten or your tubing may be blocked by pinching)

If the RayDrop has been manipulated (for cleaning or maintenance) the four screws might not be tightened enough.

Use an allen key to tighten.

It is important to clean the RayDrop after each experiment in order to prevent clogging.

Refer to the good practice guide for the detailed procedure.

Make sure that all tubing is well flushed before connecting the RayDrop.

Do you need more information?

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