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RayDrop

Droplet generator

The RayDrop is a microfluidic droplet generator composed of three main parts fully removable: two inserts on each side and a center section containing a nozzle and an outlet capillary. There are four standard microfluidic connections, two on the box for the continuous phase, and one on each insert for the dispersed phase entry and the collecting emulsion outlet.

The RayDrop specific design allows for multiple liquid type emulsification, within the same device without any coating needed.
This allows to cover single and complex emulsion such as Double emulsion.

This allows to cover many application from encapsulation of active pharmaceutical ingredient in both polymer microparticle and microcapsule to cell and fragrance encapsulation in hydrogel microbeads such as:

  • PLGA microparticle
  • Polymer microcapsule
  • Alginate microbeads
  • Liposome Nanoparticle

BENEFITS AND FEATURE

Droplet size from 70µm to 150µm diameter

One device for multiple applications

Easy to clean

Easy cleaning

Perform double emulsion in one single device

Single and Double emulsion production

Highly flexible (w/o/w or o/w/o)

No coating needed

High monodispersity

High monodispersity

technology

Raydrop Single emulsion:

The RayDrop works as a co-flow focusing principle. The nozzle and outlet capillary are aligned in continuous phase chamber, the dispersed phase comes through the nozzle to create the microparticles into the continuous phase and exit by the outlet insert.

RayDrop Single emulsion principle

The RayDrop is available in three standard configuration (Nozzle size-Extraction capillary size), in order to target a broader droplet size range:

• 30µm-150µm
• 60µm-300µm
• 90µm-450µm

water in oil

As all cappilaries from the RayDrop are easily excheangable it’s easy to changee either the nozzle capillary or the collecting cappilary with another nozzle or cappilary size.
It can also be tuned to target different droplet size by changing cappilaries size and nozzle configuration:

Small droplet configuration:
30µm-60µm

Double nozzle alginate

This two nozzle configuration allow to decrease double emulsion size down to 15µm droplet size.

Raydrop Double emulsion:

The RayDrop works as a co-flow focusing principle. The nozzle and outlet capillary are aligned in continuous phase chamber, the dispersed phase comes through the nozzle to create the microparticles into the continuous phase and exit by the outlet insert.

 

RayDrop_Double Emulsion_principle

The RayDrop Double emulsion is available in a standard configuration (Core Nozzle size-Shell Nozzle size-Extraction capillary size)

• 30µm-70µm-150µm

As all cappilaries from the RayDrop are easily excheangable it’s easy to changee either the nozzle capillary or the collecting cappilary with another nozzle or cappilary size.
It can also be tuned to target different droplet size by changing cappialries size and nozzle configuration:

Small droplet configuration:
30µm-70µm-90µm

Double nozzle double emulsion

This two nozzle configuration allow to decrease double emulsion size down to 50µm double emulsion size.

APPLICATION

SINGLE EMULSION

Alginate microbeads production

droplets alginate (2)

PLGA microparticle synthesis

vaccin application microfluidics

Liposome nanoparticle production

liposome nanoparticle

Water in oil emulsions

water in oil

Oil in water emulsions

oil in water

Water in fluorocarbon oil emulsion

AlllinWater_70_5_C001H001S0002000017

UV resin polymerised microparticle

Resin microparticle

DOUBLE EMULSION

Water in oil in Water

double emulsion

Oil in water in Oil

Oil in Water in Oil

UV resin polymerised microcapsule

Resin microcapsule

Estimate the size of your Droplet with the Raydrop

Estimate the size of your Droplet with the Raydrop

Related video and webinar

ayDrop Tuto Filling -FLUIGENT

Other videos :

  • [Webinar Replay] – Master the production of double emulsions
  • [Webinar Replay] – Raydrop, a universal droplet generator based on a non-embedded co-flow focusing
  • [Webinar Replay] – Webinar Drug encapsulation in biocompatible microparticle
  • [App Note video] – Microfluidics for Alginate Microbeads Production
  • [Tutorial video] – Double Emulsion Production: Raydrop Method

Product offering

Raydrop Single emulsion:

Raydrop products

 

PN Product name Capillary sizes Nozzle type
1DPRD01 Complete Raydrop 30µm-150µm Methacrylate Resin
ORDRPSE-60-300 Complete Raydrop 60µm-300µm Methacrylate Resin
ORDRPSE-90-450 Complete Raydrop 90µm-450µm Methacrylate Resin
O-SE-RDRPC04-EUP Complete Raydrop 30µm-60µm Methacrylate Resin
O-SE-RDRPC05-EUP Complete Raydrop 30µm-90µm Methacrylate Resin
O-SE-RDRPC06-EUP Complete Raydrop 60µm-90µm Methacrylate Resin
ORDRPSNO-30 Simple nozzle insert 30µm Methacrylate Resin
ORDRPSNO-60 Simple nozzle insert 60µm Methacrylate Resin
ORDRPSNO-90 Simple nozzle insert 90µm Methacrylate Resin
ORDRPCOL-150 Collecting capillary insert 150µm Glass
O-SP-CCI300-CO Collecting capillary insert 300µm Glass
O-SP-CCI450-CO Collecting capillary insert 450µm Glass
O-SE-RDRPC01G-EUP Complete Raydrop 30µm-150µm Glass
O-SE-RDRPC02G-EUP Complete Raydrop 60µm-300µm Glass
O-SE-RDRPC03G-EUP Complete Raydrop 90µm-450µm Glass
O-SE-GSNO30-EUP Simple nozzle insert 30µm Glass
O-SE-GSNO60-EUP Simple nozzle insert 60µm Glass
O-SE-GSNO90-EUP Simple nozzle insert 90µm Glass

Complete applicative  solution including Raydrop

 

PN Product name Application
1DPPL01 PLGA microparticule production station SP PLGA microparticle production
O-SE-PLGAAP-PCK PLGA microparticule production station AP PLGA microparticle production
O-SE-ALG-PCK Alginate microbeads production station Alginate microbeads production
O-MIX-LIPO-PCK Liposome nanoparticle production station Liposome nanoparticle production

For custom solution or specific application

Raydrop Double emulsion:

Raydrop products

 

PN Product name Capillary sizes Nozzle type
ORDRPDE-30-70-150 Complete Raydrop 30µm-70µm-150µm Methacrylate Resin
O-DE-RDRPC04-EUP Complete Raydrop 30µm-70µm-90µm Methacrylate Resin
O-SP-DNI3070-CO Double nozzle insert 30µm-70µm Methacrylate Resin
ORDRPSNO-90 Simple nozzle insert 90µm Methacrylate Resin
ORDRPSNO-60 Simple nozzle insert 60µm Methacrylate Resin
ORDRPCOL-150 Collecting capillary insert 150µm Glass

Complete applicative  solution including Raydrop

 

PN Product name Application
O-DE-STD-PCK Double emulsion production station Double emulsion production

For custom solution or specific application

SPECIFICATION

SINGLE EMULSION

Raydrop Single emulsion:

single emulsion specification

DOUBLE EMULSION

Raydrop Double emulsion:

double emulsion specification

Testimonial

“My team has started using the Fluigent microfluidic kit for making polymer based particles. We tried different microfluidic systems in the past but unfortunately they were not suitable for our application. The main issue was chip blockage which rendered the process quite laborious.

The RayDrop microfluidic chip from Fluigent gave us the best results with a better control over the process.

I have to mention the excellent technical support from Fluigent, their team visited my lab 3 times to deliver training and help to optimize the process”

Dr Omar QUTACHI

Senior Lecturer in Pharmaceutics

Health and Life Sciences

De Montfort University , The Gateway, Leicester

icon questions

FAQ

As chemicals, can be used ethylacetate, ethanol or IPA. (The nozzle material is not compatible at long-term use with dichloromethane)

 

icon green tick
Ethyl acetate molecule
icon green tick
Ethanol molecule
icon green tick
IPA molecule
icon red cross
Dichloromethane molecule

Ethyl acetate

Ethanol

IPA

Dichloromethane

Yes, we recommend filtering all solutions before starting your experiment. The presence of dust can block the nozzle.

Open the top plugs of the RayDrop.

Return to the RayDrop filling state.

Refer to the application note protocol.

Leaks can sometimes appear if the fluidic connectors are not tightened enough.

 

 

 

 

 

Check that all the connectors are attached firmly.

 

 

 

 

 

 

(Be careful not to over tighten or your tubing may be blocked by pinching)

If the RayDrop has been manipulated (for cleaning or maintenance) the four screws might not be tightened enough.

Use an allen key to tighten.

It is important to clean the RayDrop after each experiment in order to prevent clogging.

Refer to the good practice guide for the detailed procedure.

Make sure that all tubing is well flushed before connecting the RayDrop.

Do you need more information?

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