Nanoparticle Production Pack

[O-MIX-LIPO-PCK] or [O-MIX-PLGANP-PCK]

Complete system for producing nanoparticles in a reproducible manner

A nanoparticle is defined as a particle with dimensions below the micrometer range. Typically, their diameter ranges between a few dozen and a few hundred nanometers. In particular, liposomes are nano-vesicles of spherical shape with a lipid bilayer. They are commonly used as carriers for active pharmaceuticals ingredients.

The Fluigent Nanoparticles Production Pack is a robust and complete system for precise and long-term production of nanoparticles, including liposomes, with high flexibility in the particle size range. The pack includes Fluigent’s LineUP microfluidic pumps and Secoya's RayDrop device – a breakthrough in high-quality particle production technology.

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Main benefits

High precision
< 2% CV
Flexible
Adjustable particle size
Robust
Continuous production

Features of the Pack

Complete System

With this nanoparticle production pack, users have all the components needed to start generating nanoparticles with high monodispersity and high stability.

Dedicated Protocol

A protocol is available to assist users in setting up and starting their experiments.

Engineered Solution

We built the nanoparticle station with the right pressure controllers, microfluidic chips, and valves to give you the greatest possible flexibility in terms of particle size and generation rate.

Customization

We can adapt the package to meet your needs (particle size, generation rate).

Related applications

Fluigent products manual
Nanoparticle Production Station User Manual
Download

nanoparticle PRODUCTION chip fluigent raydrop

Developed and manufactured by Secoya

Why use microfluidics for nanoparticle synthesis?

Conventional methods for nanoparticle production rely on bulk protocols such as precipitation, chemical reduction, microemulsions or seeding. While these techniques are easy to handle, an overall lack of control over the particle size and poor batch-to-batch reproducibility make them unsuitable for biomedical applications such as drug development or diagnostics. Microfluidics, the method used in this nanoparticle station, appeared in the 2010s as a powerful tool to overcome these limitations.

Its ability to generate control fluid flows and chemical exchanges in a reproducible manner allows users to produce large quantities of nanoparticles with a precise diameter, excellent monodispersity, and high reproducibility.

Main Products of the Nanoparticle station

With the components of the nanoparticle production pack, users can produce nanoparticles and liposomes with high monodispersity. This pack controls the size of the nanoparticles, increasing the range of applications in which they can be used.

_{Figure 1 : Liposome Production Station Setup [O-MIX-LIPO-PCK]}

*_{Figure 2 : PLGA Nanoparticle Production Station Setup [O-MIX-PLGANP-PCK]}*

Specifications

LineUp Flow EZ pressure controller (2000 mbar) x2

LineUp LINK Module (software control) x1

FLOW UNIT M (x1) and L (x1)

P-CAP series 15 mL (x3)

LineUp Switch EZ (x1)

2-SWITCH x2

Raydrop Single Emulsions x1

SWITCH EZ x1

Liposome Nanoparticles Production

Inner phase	Absolute ethanol + Lipids 10 mg/mL + Dimethyldioctadecylammonium (DDAB) 2.5 mg/mL
Outer phase	Phosphate-buffered saline (PBS) (pH 7.2)
Particle size range	30 nm to 150 nm
Polydispersity	From 7% to 15%

PLGA Nanoparticles Production

Inner phase	Acetone + Poly(lactic-co-glycolic acid) (PLGA) Resomer 756 1%hanol + Lipids 10 mg/mL + Dimethyldioctadecylammonium (DDAB) 2.5 mg/mL
Outer phase	Deionized water + Polyvinyl alcohol (PLGA) Mw 90000 – 10000 80 % hydrolyzed
Particle size range	100 to 250 nm
Polydispersity	From 5% to 15%

Flow Control

Pumps	Fluigent Flow EZ (2000mbar)
Flow Sensors	Fluigent FLOW UNIT (M & L)
Automated valves	Fluigent 2-SWITCH

Imaging (optional)

Microscope

Fluigent Digital high-speed microscope

OxyGEN

Control in real-time, protocol automation, data record and export

ver. 2.2.0.0 or more recent

See the offer

Software Development Kit

Custom software application

ver. 22.2.0.0 or more recent

See the offer

Imaging

Pixelink Capture Software

	Extrusion method	Fluigent microfluidic method
Particle size distribution	up to 50%	~ 2%
Reproducibility	low	High
Particle size control	no	Precise
Continuous (in line) production	no	yes

Nanoparticle Production Pack