Microfluidics case studies

Fluigent is driven by the success of our research and OEM customers. In addition to providing high-performance microfluidic modules, we have our customers benefit from more than 15 years of experience in microfluidic liquid handling and focus on providing the highest level of support to enhance your experiments. Hear from Fluigent customers and OEM partners about their experience working with us in the microfluidics case studies below. “Fluigent pressure controllers allowed us to inject our sample solutions under constant pressure, which guarantees highly accurate resistive pulse sensing measurement.” Prof. Xuexin Duan – Tianjin University, Department of Precision Instrument Engineering

Study summary of Artery-on-Chip model

Microfluidics case studies

A microfluidic Artery-on-a-Chip using Fluigent’s Microfluidic Flow Control System, the MFCS

Innovative Artery-on-a-Chip bridges cell culture and animals, advancing cardiovascular research for prevention, diagnostics, and therapy.

Overview of the Bood vessels-on-a-chip perfusion model

Microfluidics case studies

A multiplex microfluidic circuit for blood vessel-on-a-chip perfusion using Fluigent’s FlowEZ

A perfusion platform to apply bi-modal mechanical stimulation wall shear stress (WSS) and circumferential strain to up to 12 blood vessel-on-a-chip simultaneously.

automated immunolabeling ibex aria human jejunum

Microfluidics case studies

Automated immunolabeling to perform highly multiplexed tissue imaging with ARIA

Understanding cell-cell interactions and spatial relationships in healthy or diseased organs represents a technical challenge. Single-cell genomics is powerful but lacks spatial context. In this study, automated immunolabeling has been applied to obtain a versatile multiplex optical imaging approach for deep phenotyping and spatial analysis of cells in complex tissues.

Fluidic actuation of the flow cell

Microfluidics case studies

CEA/CNRS: A flow cell for nanoscopic imaging in liquid

Development of a flow cell for nanoscopic imaging to analyze inorganic particles in water using nanoscope imaging technology.

liver-on-a-chip model

Microfluidics case studies

CNRS/UTC: study of a liver-on-a-chip model

Microfluidic systems are being developed as it is perfectly suited to making miniaturized, robust and controllable systems involving fluid handling and biological functions, such as human liver-on-a-chip models for instance. Use of Fluigent products for characterizing the microfluidic culture of liver tissue.

Microfluidics case studies

Controlled Flow System for Altering Cardiac Mechanical Load in Zebrafish Model

A precise flow control system and micro-cannula injection method were developed to regulate atrial preload and assess cardiac function in zebrafish larvae.

Cancer-on-a-chip platform

Microfluidics case studies

Creating a Microfluidic Cancer-on-Chip Platform using Fluigent’s High Throughput Cell Perfusion Pack

Immunofluorescent images of DAPI-PECAM-GFP of organoids co-cultured with GFP+ HUVECs

Microfluidics case studies

Creating kidney organoids‑vasculature interaction model using Fluigent’s Flow-EZ

This study is the first to achieve vascularization of kidney organoids in HUVEC co-culture conditions using a microfluidic organ-on-chip. This model offers valuable insights into kidney organoid vascularization and is a promising tool for studying kidney development and drug testing.

Fluorescence microscopy of A2780 with liposomes labeled with rhodamine B

Microfluidics case studies

Drug-Loaded Liposome Preparation Using Microfluidics

Liposome preparation using a complete microfluidic setup (pressure controller) to encapsulate amiodarone, a promising drug in ovarian cancer.

scheme of SliceChip ex vivo pancreas assembly

Microfluidics case studies

Flow-EZ and SliceChip for Pancreas on a Chip Study

Dr. Agarwal’s Physiomimetic Microsystems Laboratory (PML) developed the microfluidic pancreas-on-chip platform that can provide controlled oxygen and perfusion environments for viability and real-time imaging.

Photo of the microfluidic 3D printer

Microfluidics case studies

Microfluidic 3D Printing for High-Resolution Multimaterial Fabrication

Microfluidic 3D printing combines flow control and laser lithography to create high-resolution multimaterial structures, enabling advanced cell culture and bioprinting.

Skin-on-chip

Microfluidics case studies

Microfluidic Artificial Skin Platform for Sweat Study and Product Development

This article presents a microfluidics model to mimic skin for sudation research. Our flow controller permits a precise distribution of sweat in artificial skin.

Droplet Changes to H/F/W

Microfluidics case studies

Microfluidic Control of Complex Emulsions for Chemical Sensing

This case study highlights Rakesh et al.’s successful application of complex emulsions to advance real-time flow sensing technology.

The Bells Lab picture

Microfluidics case studies

Microfluidic Transistor for Precise Fluid Control

This study introduces a microfluidic transistor, mimicking electronic behavior, enabling precise fluid control in lab-on-a-chip systems.

Standard deviation analysis

Microfluidics case studies

Mimicking tumor microenvironment using a 3D microfluidic model to improve cancer investigations

New 3D model for cancer investigations based on the mimicking of tumor microenvironment using pressure pump to recreate interstitial flow.

oem customised automated drug screening system

Microfluidics case studies

OEM Case Study: Microfluidic Drug Screening

tongue on chip scheme

Microfluidics case studies

Programmable Injections of Sweeteners with the Fluigent Flow-EZ for Tongue-on-a-chip Receptomics Taste Assay

The microfluidic receptomics-based tongue-on-a-chip platform assesses how taste receptor live cells respond to different sweeteners.

Ocular routes for drug delivery

Microfluidics case studies

Real-Time Monitoring Platform for Ocular Drug Delivery, Integrating Fluigent’s Flow EZ

This customer case study introduces an innovative platform, including Fluigent’s pressure controllers and valves, for ocular drug delivery monitoring.

Precise and smooth pressure-based cell pipetting

Microfluidics case studies

Success story of SEED Biosciences: Single cell impedance analysis

Unlock cellular insights with single cell impedance analysis. Explore SEED Biosciences case story and their flow injection analysis single cell method development.

Epigenomics Ram Laboratory Single cell sequencing

Microfluidics case studies

The Hebrew University: Encapsulation and culture in 3D hydrogels for Single cell sequencing

CloneSeq: A highly sensitive single-cell analysis platform for the comprehensive characterization of cells from 3D culture.

Mbios-tianjin

Microfluidics case studies

The Micro/Nano Bioelectronics and Biosensors (MBIOS) from Tianjin University

University-of-Cambridge

Microfluidics case studies

University of Cambridge: Microfluidic GUV production and testing

The use of Fluigent pressure-based flow controllers has been a key factor in achieving microfluidic GUV production using the OLA method, facilitating the production of vesicles with higher monodispersity and size control.

Maryland University - microfluidic system for robotic

Microfluidics case studies

University of Maryland: Microfluidic System for Robotic that can Play Nintendo

Discover the precision of our microfluidic system: A soft robotic hand with integrated fluidic circuitry that can play Nintendo Mario Bros

Photonic Sensor-Enabled Tissue Chip

Microfluidics case studies

University of Rochester: A tissue chip platform for real-time sensing of secreted inflammatory markers using ARIA

Development of a cutting-edge technology that utilizes a state-of-the-art microfluidic system in the context of a novel tissue chip platform.

droplet surfactant microfluidic

Microfluidics case studies

Using dSurf for High Throughput Laser-Induced Fluorescence Droplet Micro-Thermometry (LuMIn)

This paper assesses a new temperature measurement method at the micro-scale at high throughput.

Microscopic image of biofilm on a catheter

Microfluidics case studies

UV-C and microfluidics for biofilm studies as a new experimentation method

Method for the microfluidic study of bacterial biofilms using pressure pump coupled with UV-C emission to target biofilm formation in an area of interest.