Compact platform for organ-specific environment experiments
Fluigent has partnered with Micronit to offer a versatil fully integrated Organ-on-a-Chip Platform which reproduces numerous characteristics of the cell in vivo environment.
The platform is a robust technology and compact system which produces a stable flow-rate and pressure for increased cell growth in long-term experiments and allows liquid and gas handling mimicking mechanical stretching.
- Compact: up to 16 chips in parallel in classic size incubators*
- Versatile chip: 2 resealable slides with cell culture membrane
- Plug and Play: Ability to control gas or liquids with various flow profiles
- Pressure-based microfluidics: High repeatability, time saving and very fast response times.
The Fluigent/Micronit Organ-on-a-Chip kit focuses on modeling the main biochemical and biophysical features of the native environment of cells in order to induce their growth and differentiation as functional tissues.
Air-liquid interface, flow induced shear stress, mechanical stimulation, biochemical gratdient or cell-cell coculture have been reported to significantly improve the functionality of in vitro models. All these parameters can be controlled by the Organ-on-a-Chip kit system
The Organ-on-a-Chip kit is composed of multiple microfluidic components :
- Flow EZ
- Flow Units
- A Micronit chip and chip holder
Because CTCs detection and labelling need a very precise and smooth flow control, Fluigent MFCS™ associated with the Flow-Rate Control Module and the ESS™ platform, was the designated choice to be able to efficiently control the flows of all the solutions and samples.
Many microfluidic applications require switching between multiple solutions (such as samples or buffers) while maintaining a constant flow-rate during the course of their experiment. In this application, one MFCS™-EZ pressure channel is connected via a manifold to ten separate vials containing different aqueous solutions.
Many microfluidic applications are developed based on concepts relying on electrodes, exploiting the electrical properties of samples to sort or separate them, generate electro-osmotic flows, manipulate particles, perform electrochemical detection etc. One example of this is electronic paper, where the electrophoretic displacement of titanium dioxide particles in a dark hydrocarbon oil solution allows the formation […]