Double emulsion for the generation of microcapsules - a Review

In this white paper, we synthetized the production of microcapsules of various materials ranging between 40µm and 250µm. The microfluidic system is described below, along with the chemicals used and the optimal concentrations.

Controlled double emulsification process for encapsulation

Using droplet-based microfluidics as a method for generating microcapsules is of growing interest in the scientific community, as it offers great potential in delivering active pharmaceuticals ingredients (APIs). The molecule can be encapsulated in the core of the droplets, surrounded by a protective shell that enables the transport of the drug to specific locations of the body, while eliminating, unwanted secondary effects and collateral damages.

While conventional bulk methods for the generation of microcapsules are limited by droplet polydispersity and high reagent loss, microfluidics offers a way to produce highly-monodisperse double emulsions with a higher encapsulation efficiency. Here, we present different ways to generate double emulsions for microcapsule production using the complex emulsion platform, developed by Secoya and equipped with our pressure-based flow control technology.

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I. Terminology

II. Introduction

III. Equipment

a. The Raydrop

b. Microfluidic double emulsion platform

IV. Use case 1: Chitosan microcapsules

V. Use case 2: Agarose microcapsules

VI. Use case 3: Alginate microcapsules

VII. Use case 4: PLGA microcapsules

VIII. Use case 5: Polymethacrylate resins microcapsules

References

Next Webinar Incoming

Complex Microfluidic Emulsions: How to Optimize Production, Flow Control & Monodispersity

May 22, 2025 – Get the best of Flow Control Technologies to perform highly monodispersed droplets. Learn everything you need in our exclusive webinar.

✅ Precision in Emulsion Creation using the RayDrop from Secoya

✅ Mastering Flow Control through FlowEZ Pressure pump from Fluigent

✅Case Study: Fluorescent Complex Emulsions

May 22, 2025