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Home » Research » Microfluidic Instruments » Omi, an Automated Organ-On-A-Chip Platform

Omi, an Automated Organ-On-A-Chip Platform

[O-OMISC-PTF]
  • New release

Mimic Microphysiological Conditions in Organ-on-a-Chip Studies

The Omi is an automated platform that helps control the microphysiological fluidic environment of organ cells inside microfluidic chips. With multiple protocol functions (perfusion, recirculation, sampling, and drug delivery), the Omi ensures precise shear stress control and supports long-term recirculation. It is compatible with any type of chip to sustain different cell culture types or organ-on-a-chip models (liver, gut, skin, etc.).

Ask for a quote or a demoSpecifications
Main benefits
  • Designed for biology

    Suited for cell culture under sterile conditions.

  • Versatile

    Can be used with virtually any microfluidic chip design.

  • Cost effective
    Efficient

    Automated and fully integrated platform (Shear stress, flow rate, and pressure control).

  • USER FRIENDLY
    Easy-to-use

    Intuitive interface and technology for beginners and advanced researchers.

Applications: Control Your Experiment With Fluigent’s Omi   

The Omi is ideal for cellular organ models, drug discovery, ADME-Tox and Safety. 

Single Channel Configuration

  • Blood Vessel Reproduction: Reproduce precise shear stress conditions of blood vessels with endothelial cells-on-chip using the Omi organ-on-a-chip system. 
HUVEC cells before connexion to Omi
HUVEC cells before connection to Omi platform.
HUVEC after 7 days of culture media recirculation with Omi
HUVEC after 7 days of culture media recirculation with Omi

  • Microfluidic Application Notes

    Endothelial Cell Culture Under Shear Stress Using Omi

    Read more
  • Gut-on-chip: Achieve optimal flow control and sustained culture conditions, enhancing cell differentiation, nutrient delivery, and intestinal barrier function to accurately replicate the human intestine. 
Caco2 cells before Omi
Caco2 cells before connection to Omi
Caco2 cells after 7 days of culture medium recirculation with Omi
Caco2 cells after 7 days of culture medium recirculation with Omi

  • Microfluidic Application Notes

    Gut-on-Chip Model Development Using OOAC Platform, Omi

    Read more
  • Cancer Drug Discovery

Mimic the effect of drug compounds on tumor cells to evaluate their response to treatments. 

  • Support & Tools

    Shear Stress Calculator

    Explore more

Double Channel Configuration

  • Liquid / Liquid interface:

When the Omi’s fluidic system is paired in two, it allows users to model liquid-liquid interfaces to reproduce physiological functions of different human organ models. 

  • Blood-Brain-Barrier:

Assess vascular permeability and brain cells-on-chip. Our microfluidic functionalities and protocols allow for accurate cell organization and physiology to study the microenvironment of the human brain.  

Discover more about organ-on-a-chip technology and its diverse applications with our white paper. 

guillemet

« I’m thrilled to share that I’ve used Omi on numerous occasions for my cell biology experiments as part of my PhD. Omi is the simplest tool I’ve been able to use for on-chip organ recirculation and perfusion. Everything is integrated into a single device, and the sterile consumables are easy to use, which greatly reduces the risk of contamination. 
Tablet and web applications allow real-time monitoring of experiments in progress, making it the perfect user-friendly tool. I’m really excited to be able to develop new biological applications with Omi! »

Arthur Salles – PhD Student  

CNRS LIED – Team « Microsystèmes Cellulaires » – Université Paris Cité 

Free contents that might interest you

  • Fluigent Products Datasheets

    Omi Fluigent Technical Datasheet

    Download
  • Fluigent products manual

    Omi Fluigent User Manual

    Download
  • gut on chip webinar image

    Webinar: Importance of Flow in Organ-on-a-Chip, featuring the Gut-on-a-Chip Model

    Explore more
  • Register to Omi webinar

    Webinar – Mastering Microphysiological Precision with Omi

    Explore more
webinar flow in ooac replay banner

Several Protocol Functions Can Be Produced with a Single OMI Platform

Perfusion

Perfuse up to 3 mL of several types of liquids such as cell culture media for long periods of time in a controlled and reproducible way. The Omi can perfuse culture media at low flow rates, making it easier to maintain sensitive spheroid and organoid cultures within microfluidic chips. 

Recirculation

The microfluidic organ on chip system can produce unidirectional recirculation of  mediawhile maintaining user defined flow rates with high precision. Read our technical note on long-term recirculation for organ-on-a-chip applications. 

Sampling

Sample up to 3 mL of soluble factors secreted in the culture medium for analysis or imaging. 

Injection

Inject up to 3 mL of fresh medium during an experiment. 

Flow rate and pressure rate monitoring omi

Flow rate and pressure rate monitoring over time for 50 µL/min 

You want to book a demo or talk to an expert?

Get in touch!

Designed to fit in incubators, and easy to transport to a microscope for imaging or cell analysis

Completely autonomous platform 

The Omi features a two-hour battery backup supplyfor uninterrupted operation. In addition,  Wi-Fi or Bluetooth connectivity ensures  easy setup and monitoring of your protocols through its user-friendly application interface. It can easily be transported from an incubator to a microscope to perform live cell imaging while maintaining cell perfusion under battery power. 

omi in situation under a microscope and connected to the soft
omi fluigent Reproducibility and experiment duplication

Reproducibility and experimental versatility 

The Omi automated perfusion platform can be used in different modes: 

Single mode : single channel perfusion for cell culture, such as blood vessel 

Dual mode: double channel perfusion for co culture to perform liquid/liquid interface or blood-brain barrier  by synchronizing two Omis with one organ-on-a-chip. 

Compact and Transportable: One incubator, several Omis 

This space saving platform allows multiple Omis  inside a single incubator for a given experiment. Units can be easily transported to a microscope for real-time monitoring while maintaining perfusion. 

fluigent omi organ on a chip platform
Injection of cell or fresh medium in omi

Contamination-free

Inject cell or fresh medium, deliver test compounds, collect samples without disconnecting the microfluidic chip and disturbing the experiments. 

Specifications

PERFORMANCE

Flow rate controlFrom 1 µL/min to 1 mL/min*
Maximum pressure600 mbar at maximum
Fluid reservoir volume3 mL
Perfusion / Injection / Sampling volumeFrom 1 mL to 3 mL
Min volume recirculated2 mL

* The flow rate depends on the microfluidic chip and the adaptator.

HARDWARE SPECIFICATIONS

Dimensions (L*W*H)190 x 120 x 60 (mm)
Weight694 g
Operating temperature15-40°C
Gas input pressureAtmospheric pressure
Gas input compositionDry 2 µm-filtered air, O2/CO2 mix or incubator air 

ELECTRONICAL SPECIFICATIONS

Power supply voltage24 V DC
Max energy consumption12 W
Max current requirement0.5 A
Battery autonomy2 h

CARTRIDGE SPECIFICATIONS

Dimensions80 x 60 x 36 (mm)
Weight56 g
MaterialsMedical grade polycarbonate and MVQ silicone*
Working fluidsWater based solutions, IPA, Ethanol
CleaningIsopropanol, 80%/20% v/v water ethanol solution, tergazyme 1% 

*Check the material compatibility of solutions with the wetted materials available in the Omi’s Datasheet 

TUBING SPECIFICATIONS

MaterialFEP (provided) , but other materials possible depending on the connector
ID250 μm (provided), but other can be used depending on the application
OD1/16” (provided), but other can be used with a compatible 1⁄4-28 flat bottom connector

Omi SOFTWARE (tablet)

Control in real-time, protocol automation, data record and export
ver. 1.2.3  or more recent

*Provided with the Omi device

https://play.google.com/store/apps/details?id=com.fluigent.omi


Omi WEB:

Manage your team and monitor your running experiments 

https://omi.fluigent.com/login

1. Can I clean the disposable elements to reuse them?   

No. These disposables are for one time use.  If the disposables are reused, Fluigent cannot guarantee accurate results.  

2. Can I use ethanol or isopropanol in my protocols? 

 No, only during cleaning and sterilization steps. 

3. How many experiments can I run with the disposables without replacement?  

One experiment can be run from several hours up to multiple weeks. 

4. How can I clean the Omi organ-on-a-chip system?  

For the external cleaning of the device, gently wipe the surface with a tissue and ethanol or isopropanol. 

For the cleaning of the fluidic part, we highly recommend following the specific cleaning protocol that can be found in the Omi App protocol editor. Manual cleaning can be performed using the Omi manual mode by recirculating your own detergent through the system. 

5. How many Omi devices can I control with my tablet?  

Users can monitor up to 12 Omi devices with the tablet. In the Omi app on the homepage, up to six devices are visible at once. When you have more than six devices, you must scroll left to the second page to see the other devices. When launching an experiment with the Omi, you will receive data every two or three seconds from the six devices present on the homepage. The devices that are not visible on the homepage are monitored every 30 seconds.

6. Can I use my own tablet to control the Omi?  

Fluigent provides a tablet with the purchase of an Omi. Other tablets can be used, but we do not guarantee the same performance.  


Expertise & resources

  • Microfluidic Application Notes Gut-on-Chip Model Development Using OOAC Platform, Omi Read more
  • Microfluidic Application Notes Endothelial Cell Culture Under Shear Stress Using Omi Read more
  • Microfluidic Application Notes Long-term fluid recirculation system for Organ-on-a-Chip applications Read more
  • Microfluidics Case Studies CNRS/UTC: study of a liver-on-a-chip model Read more
  • Fluigent products manual Omi Fluigent User Manual Download
  • Fluigent Products Datasheets Omi Fluigent Technical Datasheet Download
  • Expert Reviews: Basics of Microfluidics Why Control Shear Stress in Cell Biology? Read more
  • Expert Reviews: Basics of Microfluidics Key considerations for fluidic system integration  Read more
  • Microfluidic Application Notes Peristaltic Pump vs Pressure-Based Microfluidic Flow Control for Organ on Chip applications Read more
  • Expert Reviews: Basics of Microfluidics Mimicking in-vivo environments: biochemical and biomechanical stimulation  Read more

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