Webinar - Liver–Kidney OOC Model to Investigate Drug Disposition
Join us for an online session exploring dual organ-on-a-chip (OOC) model supported by Omi™ OOAC Platform advances the study of drug disposition.
Using tacrolimus, a widely prescribed immunosuppressant with known nephrotoxic risks, this session demonstrates how a liver–kidney OOC platform can reveal pharmacokinetic processes, such as hepatic metabolism and renal clearance of tacrolimus and transporter dynamics influencing drug accumulation and elimination.
By recreating cross-organ communication in a microfluidic system, this platform offers human-relevant insights for pharmacology, transplantation research, and precision medicine.
📅 Date: October 30th, 2025. Get your spot!
🕓 Time: 4:00 PM CEST 🇫🇷 (Paris)
🇬🇧 London (BST): 3:00 PM
🇺🇸 Boston / New York (EDT): 10:00 AM
🇨🇦 Montreal / Toronto (EDT): 10:00 AM
🇺🇸 Chicago (CDT): 9:00 AM
🇺🇸 San Francisco (PDT): 7:00 AM
Agenda of the webinar:
- Dual-Organ OOC Technology: Concepts and Applications
- How microfluidics and Omi™ enable advanced drug testing – Presented by Anel
- Case Study: Tacrolimus Disposition in a Liver–Kidney OOC Model – Presented by Isy Petit
- Future Outlook in Pharmacology and Transplantation Research – Presented by Dr.Nicolas Vedrenne
- Live Interactive Q&A Session
Speakers:
- Anel Rakhmatullina – Life-Science Applications Engineer, Fluigent
- Dr. Nicolas Vedrenne – Associate Professor (MCU) in « Toxicology and Environmental Health », University of Limoges Pharmacology and Transplantation UMR 1248
- Isy Petit – PhD Candidate in « Drug Membrane Transporters », University of Limoges Pharmacology and Transplantation UMR 1248
Discover Omi, Automated Organ-on-chip platform
Omi is an automated platform that helps reproduce the microphysiological behavior of organs inside microfluidic chips. It is compatible any type of chips to sustain different cell culture types or organ on chip models (Gut, Skin…)
Building the Liver–Kidney Dual OOC Model: Access the Application Note
Tacrolimus is a commonly used immunosuppressant for liver transplant patients, but its use is limited by a narrow therapeutic window, variable pharmacokinetics, and risk of nephrotoxicity.
To better understand how the liver and kidney jointly process this drug, researchers developed a interlinked organ-on-chip (OOC) model using the Omi™ Dual Platform. This system combines HepaRG spheroids and RPTEC/TERT1 cells in a dynamic microfluidic circuit, allowing real-time study of hepatic metabolism and renal transporter activity under continuous recirculation.
Figure. Overview of Liver-Kidney Dual OOC setup
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