Uses minimum bench space
Microfluidic Flow Rate Platform
- Customize your own
Flow sensors hub
The FRP, or Flow Rate Platform, is a compact device that integrates multiple bidirectional individual microfluidic flow sensors (FLOW UNIT). Either 4 or 8 sensors are available, each offering different low flow rate ranges.
When combined with LineUp™ or MFCS™ series instruments, the flow rate can be controlled through our advanced Direct Flow Control (DFC) algorithm. This allows for the pressure to automatically adapt to maintain the desired flow rate.
Main benefits
Compact
Wide rangeMeasurements from nL/min to mL/min
Designed for Life Science ApplicationsSuited for cell culture under sterile conditions
IntuitiveStraight forward set up & use
Features Of the Platform
Precise Flow Rate Measurement or control over a wide Range
The multiple flow sensor platform enables , real time measurements and control of liquid over a wide range of flow rates – from 3.7 nL/min to 5 mL/min.
Two versions available
The FRP is designed for flexibility, allowing you to choose between two versions: FRP4 (4 flow sensors or FRP8 (8 flow sensors).
Monitor, Control & Automate Experiments
Bidirectional flow rate measurements from all FLOW UNIT sensors are displayed in Fluigent’s software providing instant monitoring. Additionally, the software can track and record the dispensed volume for each sensor.
When combined with the MFCS™ and LineUp™ series instruments, the sensors enable pressure regulation through DFC (Direct Flow Control), a ‘self-learning’ flow rate control algorithm, allowing the system to monitored or control flow rate rather than pressure.
Compatible with biological conditions.
The flow rate sensor hub is designed for optimal use in biological environments, including in incubators at 37 degrees C. I The wetted materials (glass) ensure biocompatibility.
Control Your System Using Flow Rate
In cell perfusion applications, precise flow rate control is importan tomaintain cell viability, mimic physiological conditions and control shear stress.
Our Cell Perfusion Pack, combining pressure controllers with our flow control platform, offers an ideal solution for microfluidic perfusion. It is compatible with a variety of applications, including drug screening, disease modeling, toxicity testing, and personalized medicine. For example, Chakrabarty et al. developed a Cancer-on-a-Chip platform to evaluate patient-specific treatment responses, enabling accurate predictions of therapeutic outcomes in breast and prostate cancer tissues (1).
The system supports the replication of pulsatile flows found in arteries, for blood vessel-on-chip models.
Specifications
Sensor performance
| Sensor model | XS | S | M | L | XL |
| Part Number | FLU-XS-8 | FLU-S-D-8 | FLU-M-D-8 | FLU-L-D-8 | FLU-XL-8 |
| Calibrated media | Water | Water IPA | Water IPA | Water IPA | Water |
| Range | 0±1.5µL/min | Water:0±7 µL/min IPA: 0±70 µL/min | Water: 0±80µL/min IPA: 0±500µL/min | Water: 0±1mL/min IPA: 0±10mL/min | 0±5mL/min |
| Accuracy (m.v.= measured value) also applies to negative values | 10% m.v. above 75 nL/ min 7.5 nL/min below 75 nL/ min | Water 5% m.v.above 0.42 µL/min 21 nL/min below 0.42 µL/min IPA 20% m.v. above 4.2 µL/min 210 nL/min below 4.2 µL/min | Water 5% m.v. above 2.4 µL/min 0.12 µL/min below 2.4 µL/min IPA 20% m.v. above 25 µL/min 5 µL/min below 25 µL/min | Water 5% m.v. above 0.04 mL/min 1.5 µL/min below 0.04 mL/min IPA 20% m.v. above 0.5 mL/min 100 µL/min below 0.5 mL/min | 5% m.v.above 0.2 mL/min 10 µL/min below 0.2 mL/min |
| Lowest detectable flow increment | 3.7 nL/min | 10 nL/min | 0.06 µL/min | 0.7 µL/min | 3 µL/min |
Mechanical specifications
| Sensor model | XS | S | M | L | XL |
| Sensor inner diameter | 25µm | 150 µm | 430 µm | 1.0 mm | 1.8 mm |
| Total internal volume | 1 µL | 1.5 µL | 5 µL | 25 µL | 80 µL |
| Maximum pressure | 200 bar | 200 bar | 100 bar | 15 bar | 15 bar |
| Wetted materials | PEEK and Quartz Glass | PEEK and Quartz Glass | PEEK and Borosilicate Glass | PEEK and Borosilicate Glass | |
| Fluid connector ports | UNF 6-40 for 1/32” OD tubing | UNF 6-40 for 1/32” OD tubing | UNF 6-40 for 1/32” OD tubing | Flangeless fitting 1/4-28 | Flangeless fitting 1/4-28 |
Product caracteristics
| FRP | FRP4 | FRP8 |
| Dimensions | 12,9 cm (l) x 7,3 cm (w) x 5.2 cm (h) | 12,9 cm (l) x 7,3 cm (w) x 5.2 cm (h) |
| Weight | 270 g | 310 g |
OxyGEN
| Control in real-time, protocol automation, data record and export |
| ver. 2.2.0.0 or more recent |
Software Development Kit
| Custom software application |
| ver. 22.2.0.0 or more recent |
Expertise & resources
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Fluigent products manual Cleaning Procedure Flow Units Download
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Fluigent Products Datasheets Flow Rate Platform Datasheet Download
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Fluigent products manual Fluigent Flow-Rate Platform User Manual Download
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Expert Reviews: Basics of Microfluidics Why Control Shear Stress in Cell Biology? Read more
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Expert Reviews: Basics of Microfluidics Passive and active mechanical stimulation in microfluidic systems Read more
Related products
References:
(1) Chakrabarty, Sanjiban, William F. Quiros-Solano, Maayke M. P. Kuijten, Ben Haspels, Sandeep Mallya, Calvin Shun Yu Lo, Amr Othman, et al. « A Microfluidic Cancer-on-Chip Platform Predicts Drug Response Using Organotypic Tumor Slice Culture ». Cancer Research 82, no 3 (1 février 2022): 51020. https://doi.org/10.1158/0008-5472.CAN-21-0799
(2) Bazban-Shotorbani, Salime, Felicity Gavins, Krishna Kant, Martin Dufva, et Nazila Kamaly. « A Biomicrofluidic Screening Platform for Dysfunctional Endothelium-Targeted Nanoparticles and Therapeutics ». Advanced NanoBiomed Research 2, no 1 (2022): 2100092. https://doi.org/10.1002/anbr.202100092.