Search results for : drug discobery

This article presents the promise of microfluidics in enhancing the characteristics of engineered nanoparticles compared to traditional bulk production methods.

We discuss some applications where microfluidics achieves results that would be very challenging to obtain when using conventional methods.

In this Application Note, PLGA nanoparticles with high monodispersity are generated using the Raydrop single emulsion developed and manufactured by Secoya, and Fluigent pressure-based flow controllers. The ability to synthesise PLGA nanoparticles in a more controllable and reproducible way creates possibilities to tailor surface properties and increase fields of application.

This application note describes the method for the production of double agarose emulsions using the RayDrop double emulsion chip and Fluigent pressure-based flow controllers. Agarose microcapsules are generated with precise control of particle, core and shell size.

Following is a method for encapsulation of reagent into alginate microbeads with total control of bead formation. A droplet-based microfluidic method is used to precisely control the production of microbeads without the drawbacks of large size distribution that present other methods.

Microbead-based microfluidics is a powerful technique for the generation of organoid cultures in 3D matrices to mimic the complex in-vivo environment that supports cell physiological and pathological behaviors.

In this Application Note, PLGA shell/aqueous core microcapsules are obtained using the Secoya Raydrop Double emulsion. The influence of the fluidic parameters on the microcapsule size and release from the oil across the shell are explored in this application note.

Complete and in-depth overview on droplet microfluidics.

The choice of the right method of fluid management can often determinate the success of a project, as well as the overall time and cost of manufacturing. Here is what you need to consider and be aware of when integrating fluidic control into your system.

Discover the concepts of OOC engineering and their applications in medical sciences.

Achieve reproducible, high-quality water in fluorocarbon oil emulsions with cutting-edge microfluidic devices. Ideal for Drop-Seq and RNA-Seq studies.

Droplet microfluidics is a powerful tool which consists of generating and manipulating micron-sized monodispersed droplets.

This review compares different flow control systems (syringe pumps, peristaltic pumps, and pressure-based controllers) focusing on their performance in terms of stability and response times.

Discover the fascinating history and evolution of microfluidic technology and how it has revolutionized various fields, from biology and medicine to industry, and applications ranging from droplet generation to life science.

In this application note, we describe the process of producing highly monodisperse alginate microparticles using droplet-based microfluidic methods to control droplet size and core-shell ratio. Different concentrations of alginate have been used to show the versatility and adaptability of the RayDrop in multiple applications.

In this Application Note, chitosan-shell/oily-core microcapsules are generated using the Raydrop double emulsion chip, and Fluigent pressure-based flow controllers. The influence of the fluidic parameters on the size and the release from the oil across the shell are studied and presented.

Cells are constantly exposed to biochemical stimulation from the early embryonic stage to adult life. The spatiotemporal regulation of these signals is essential as it determines cell fate, phenotype, metabolic activity as well as pathological behaviors. The fast response and high stability of Fluigent instruments make them the best solution available on the market to reproduce these complex variations in vitro.

Myochip: Building a 3D innervated and irrigated muscle on a chip

The aim of the European Union’s Horizon H2020 project, Myochip  is to build a muscle on chip. Myochip gathers 4 partners from all around the world: The institute of molecular medicine (Portugal), The University of Edinburg (Scotland), and Institut Curie (France).

We have demonstrated the use of Aria and its related software for the automated delivery of different liquids for the capture and labeling of cancer cells (breast cancer) using a complex microfluidic setup.

Flow rate measurement is needed for many microfluidic applications, including microfluidic droplet generation, cell culture under flow, and organs on chip. Several technologies aim to provide accurate real time flow measurement to meet this need. In this review, the different existing microfluidic flow sensing solutions for low-flow liquids are described, with their advantages and current limits, as progress is still ongoing in this field.

In this application note, we describe the encapsulation of multiple aqueous “core” droplets inside a single oil droplet called a “shell”.

In this application note, We explain how to generate water emulsions in oil solutions using the Fluigent microfluidic system including pressure pumps, chemicals, tubing and a Droplet Generator PDMS Chip.

In this application note we have demonstrated how we can perform different type of double emulsion generation with a single device.