When PLGA is used as an active pharmaceutical ingredient carrier it is important to produce highly monodispersed particles for drug release reproducibility. To reach this high monodispersity level, the RayDrop developed and manufactured by Secoya is used. The most common production process of PLGA particles is solvent based and can involve hazardous solutions. Ethyl acetate is preferred as it shows better biocompatibility than other conventional solvent such as dichloromethane.
Read how the PLGA microparticle production station allows an excellent reproducibility and significantly improved monodispersity (CV < 2%) as compared to other methods on the market in this application note.