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Mechanical Stimulation Pack

    A versatile package for mechanical stimulation of cells

    The Mechanical Stimulation Pack is designed to provide precise and accurate mechanical stimulation to your microfluidic experiments while using your own microfluidic chip. It allows you to create a wide range of mechanical stress and strain conditions on your microfluidic chip, enabling you to study cellular and molecular responses to mechanical forces.

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    Main benefits
    • USER FRIENDLY
      Easy

      Simple connections 

    • Flexible

      Can be used with different kinds of mechanical stimulation microfluidic chips 

    • Biocompatible
      Designed for cell biology

      Contamination-free, sterile

    Features of the Pack 

    Complete System

    All fluidic components are included 

    Stability

    Fluigent’s Push-Pull offers unprecedented performance in terms of stability and responsiveness 

    Versatility

    This pack can be connected to any mechanical stimulation chip design to fit your needs. 

    Customization

    We can adapt the pack to your custom mechanical stimulation microfluidic chip to fulfill your needs in terms of specific flow rates or pressures. The number of Push-Pull and Flow UNITs can be adapted to your experiments. 

    Related applications

    FLOW UNIT microfluidic flow sensor

    Bidirectional Microfluidic Flow Sensor

    Bidirectional Microfluidic Flow Sensor

    Read more
    Push-Pull, Vacuum Pressure-Based Controller

    Standalone Vacuum Pressure-Based Controller

    Standalone Vacuum Pressure-Based Controller

    Read more

    Key products in the Mechanical Stimulation Pack 

    Figure 1: Complete setup of the Mechanical Stimulation Pack 


    “The device is well-designed and allows for easy control of my microfluidic chips. What I like most is that you are independent of a computer and can directly control both positive and negative pressure.”

    Christoph Trenzinger  – Stratec

    “The Fluigent LineUp series, including the new push-pull pump, enables precise and highly controlled aspiration and respiration of liquids. The setup allows us to further advance our research in both continuous flow and droplet microfluidics.” 

    Prof. Jeroen Lammertyn, KU Leuven Belgium – Biosensors group.

    Testimonials

    Applications of the Mechanical Stimulation Pack

    At the tissue and body levels, mechanical cues play essential roles in various processes, including embryogenesis, tissue morphogenesis, vascular angiogenesis, tumor progression, and reproductive biology. They can be exerted in a continuous, temporary, cyclic, or pulsatile manner in the body. 

    Among the different mechanical cues, stretch and compression can be implemented by deforming PDMS membranes or hydrogel layers through application of positive or negative pressures with Fluigent’s Push-Pull flow controllers. Compressive forces can thus be exerted on 3D cell cultures to expose cells to compressive mechanical cues. Specific microfluidic chip designs combined with pressure controllers can be used as a platform for mechanical stimulation of 3D cell culture within hydrogel matrices. 

    Create sophisticated multi-modal stimulation patterns 

    As an example, custom-built microfluidic chips connected to Fluigent instruments enable homogeneous stretching (1), compressions (4), or more sophisticated stimulation patterns (2 and 3). (Paggi and al., 2020) Here, a PDMS membrane can be actuated by three independently pressurized chambers and a variety of programmable deflection patterns can be applied. As a result, various cell stimulation modalities can easily be created by tuning the pressure applied in the different chambers. 

    This platform was originally developed to reproduce mechanical stimulation of cartilage (Paggi et al., 2020, 2022). However, this is a highly versatile system of great interest for modeling other types of tissues which also experience complex mechanical actuation patterns in vivo. 

    Using a custom-built chip coupled to Fluigent Push-Pull pressure controllers provides excellent pressure control and an immediate switching time response.  

    Our mechanical stimulation pack offers a user-friendly and programmable interface and allows accurate application of a variety of mechanical forces on hydrogel-imbedded cells. 

    cell perfusion pack

    Read more about Mechanical Stimulation

    Read the Paper Highlight

    Specifications

    PRODUCTS

    Our Mechanical Stimulation Package contains the following :

    LineUp Push-Pull Pressure and Vacuum controller  (x3)
    LineUp LINK Module (software control) (x1)
    FLOW UNIT M (x1)
    LineUp Flow EZ Pressure controller (x1)
    P-CAP Series P-CAP series 15 mL (x2)
    Figure 2 : Complete Schematic of the Mechanical Stimulation Package

    FLUID HANDLING SYSTEM

    ProductPart Number
    LineUp Push-Pull Pressure and Vacuum controller ELUPPU001
    LineUp LINK Module (software control) LU-LNK-0002
    LineUp Flow EZ Pressure controller (x1)LU-FEZ-1000

    RESERVOIRS

    ProductPart Number
    2*15 mL Pcap with 15 mL Falcon tubeP-CAP15-HP

    FLOW METERS

    ProductPart Number
    FLOW UNIT MFLU-M-D

    TUBING

    ProductPart Number
    Tubing and connection Kit Flow UNIT M CTQ-KIT-LQ
    2*Tubing and connection Kit P-CAP 15 mL
    FEP Tubing with an ID of 500 microns
    CTQ-KIT-PC15

    OxyGEN

    Control in real-time, protocol automation, data record and export
    ver. 2.2.0.0 or more recent

    See the offer


    Software Development Kit

    Custom software application
    ver. 22.2.0.0 or more recent

    See the offer

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