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Nanoparticle Production Pack

[O-MIX-LIPO-PCK] or [O-MIX-PLGANP-PCK]

    Complete system for producing nanoparticles in a reproducible manner

    A nanoparticle is defined as a particle with dimensions below the micrometer range. Typically, their diameter ranges between a few dozen and a few hundred nanometers. In particular, liposomes are nano-vesicles of spherical shape with a lipid bilayer. They are commonly used as carriers for active pharmaceuticals ingredients.

    The Fluigent Nanoparticles Production Pack is a robust and complete system for precise and long-term production of nanoparticles, including liposomes, with high flexibility in the particle size range. The pack includes Fluigent’s LineUP microfluidic pumps and Secoya's RayDrop device – a breakthrough in high-quality particle production technology.

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    ALGINATE BEAD GENERATION PACK
    Main benefits
    • droplet monodispersity
      High precision

      < 2% CV

    • ICO_BFT size
      Flexible

      Adjustable particle size

    • ICO_BFT continuous
      Robust

      Continuous production

    Features of the Pack

    Complete System

    With this nanoparticle production pack, users have all the components needed to start generating nanoparticles with high monodispersity and high stability. 

    Dedicated Protocol

    A protocol is available to assist users in setting up and starting their experiments. 

    Engineered Solution

    We built the nanoparticle station with the right pressure controllers, microfluidic chips, and valves to give you the greatest possible flexibility in terms of particle size and generation rate. 

    Customization

    We can adapt the package to meet your needs (particle size, generation rate). 

    Related applications

    • User manuals

      Nanoparticle Production Station User Manual

      Download
    nanoparticle PRODUCTION chip fluigent raydrop

    Developed and manufactured by Secoya

    Logo-Secoya

    Why use microfluidics for nanoparticle synthesis?

    Conventional methods for nanoparticle production rely on bulk protocols such as precipitation, chemical reduction, microemulsions or seeding. While these techniques are easy to handle, an overall lack of control over the particle size and poor batch-to-batch reproducibility make them unsuitable for biomedical applications such as drug development or diagnostics. Microfluidics, the method used in this nanoparticle station, appeared in the 2010s as a powerful tool to overcome these limitations.

    Its ability to generate control fluid flows and chemical exchanges in a reproducible manner allows users to produce large quantities of nanoparticles with a precise diameter, excellent monodispersity, and high reproducibility. 

    Main Products of the Nanoparticle station

    With the components of the nanoparticle production pack, users can  produce nanoparticles and liposomes with high monodispersity. This pack controls the size of the nanoparticles, increasing the range of applications in which they can be used. 

    Figure 1 : Liposome Production Station Setup [O-MIX-LIPO-PCK]
    Figure 2 : PLGA Nanoparticle Production Station Setup [O-MIX-PLGANP-PCK]

    Specifications

    LineUp Flow EZ pressure controller (2000 mbar) x2
    LineUp LINK Module (software control) x1
    FLOW UNIT M (x1) and L (x1)
    P-CAP series 15 mL (x3)
    LineUp Switch EZ (x1)
    2-SWITCH x2
    Raydrop Single Emulsions x1
    SWITCH EZ x1

    Liposome Nanoparticles Production

    Inner phaseAbsolute ethanol + Lipids 10 mg/mL + Dimethyldioctadecylammonium (DDAB) 2.5 mg/mL
    Outer phasePhosphate-buffered saline (PBS) (pH 7.2)
    Particle size range30 nm to 150 nm
    PolydispersityFrom 7% to 15%

    PLGA Nanoparticles Production

    Inner phaseAcetone + Poly(lactic-co-glycolic acid) (PLGA) Resomer 756 1%hanol + Lipids 10 mg/mL + Dimethyldioctadecylammonium (DDAB) 2.5 mg/mL
    Outer phaseDeionized water + Polyvinyl alcohol (PLGA) Mw 90000 – 10000 80 % hydrolyzed
    Particle size range100 to 250 nm
    PolydispersityFrom 5% to 15%

    Flow Control

    PumpsFluigent Flow EZ (2000mbar)
    Flow SensorsFluigent FLOW UNIT (M & L)
    Automated valvesFluigent 2-SWITCH

    Imaging (optional)

    MicroscopeFluigent Digital high-speed microscope

    OxyGEN

    Control in real-time, protocol automation, data record and export
    ver. 2.2.0.0 or more recent

    See the offer


    Software Development Kit

    Custom software application
    ver. 22.2.0.0 or more recent

    See the offer

    Imaging

    Pixelink Capture Software

    Extrusion methodFluigent microfluidic method
    Particle size distributionup to 50%~ 2%
    ReproducibilitylowHigh
    Particle size controlnoPrecise
    Continuous (in line) productionnoyes

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