Biomechanical/biophysical characterization of cytoskeleton, nucleus, cells, tissues, organs
Morphogenesis: identify the biomechanical stimuli inducing cell proliferation, maturation and differentiation.
Mechanotaxis: study cell response to temporal or steady shear stress gradients.
Friction in biomedical devices: investigate frictional interactions between cells and the surface of the device to reduce inflammatory reactions.
Diagnosis based on biomechanical criterion: cell sorting/capture based on their deformability (ex: circulating tumor cell isolation from blood sample), biomechanical characterization of patient sample (ex: one symptom of falciparum malaria is the reduction in the deformability of infected red blood cells.)
Haemodynamics, lymph dynamics: examine hydrodynamic properties of biological fluid in physiological conditions (relevant geometries imposed by the device design coupled to consistent flow profile delivered by the flow controller)
Transport: quantify the transport of gas and nutrients under realistic conditions (flow rates, % of cell stretching (alveolus))
Figure 1: Osmo mechanical compression of a tissue confined in a microfluidic channel (Two photon imaging of intercellular space). Photo courtesy of Dr Sylvain Monnier (Institut Lumière et Matière, France).