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Droplets in Microfluidics

Microfluidic droplet experiments arouse more and more interest from scientists. Some microfluidic droplet applications are explained in this section.

Droplet generation in microfluidics is based on the use of two immiscible fluids, oil and aqueous solutions are mostly used. The droplets  are made in devices called microfluidic chips. Different physical aspects are involved in droplet generation depending on the design and material of the microfluidic chip. Among all chip designs to generate droplets, three are widespread in microfluidic area.

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The Drop-Seq protocol, is a HTP method that enables the sequencing of the mRNA from a large number of cells. The power of this technology resides in the fact that during sequencing, one can distinguish where the original information came on a cell to cell basis. This allows one to make a gene expression map of the cell, or even to distinguish cell populations within a tissue.

Droplet production using microfluidic systems was implemented for applications where monodispersity is of high importance. Flow rate stability is critical for having repeatable reactor volume and reproducible results. Syringe pumps are commonly used for generating droplets in microfluidic experiments but can show limited flow control. Pressure-based flow controllers show high-precision flow control, high reaction time, and flow monitoring is possible.

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