- Now available with direct flow rate control (Flow Unit required)
The Fluigent/Micronit organ-on-a-chip platform focuses on modeling the main biochemical and biophysical features of the native environment of cells in order to induce their growth and differentiation as functional tissues. Air-liquid interface, flow induced shear stress, mechanical stimulation, biochemical gradient, cell-cell coculture have been reported to significantly improve the functionality of in vitro models. All these parameters are controlled by the system.
Fluigent has partnered with Micronit to develop a versatile fully integrated organ on a chip platform which reproduces numerous characteristics of the in vivo environment of cells. This platform comprises a flow control system connected to a resealable glass chip separated into two flow chambers by a transversal porous membrane.
Gut-on-chip: coculture of intestinal and endothelial cells on the membrane. (i) Basal view of the membrane, (ii) transversal view of the membrane. (Nuclei: blue, actin: green, tight junctions: red). Picture courtesy of Dr Meike van der Zande, RIKILT – Wageningen University & Research, The Netherlands.