- Now available with direct flow rate control (Flow Unit required)
Micropipette aspiration is a powerful non-invasive technique to evaluate how biomechanical properties of single cells or tissue govern cell shape, cell response to mechanic stimuli, transition from nontumorigenic to tumorigenic state or morphogenesis.
The Fluigent MFCS™-EZ and Flow EZ™ pressure controllers are particularly suited for this method since it requires applying forces ranging from 10pN to 1nN accurately.
Guevorkian K, Maître JL. Micropipette aspiration: A unique tool for exploring cell and tissue mechanics in vivo. MethodsCellBiol. 2017;139:187-201
Maître JL et al, Asymmetric division of contractile domains couples cellpositioning and fate specification, Nature. 2016 Aug 18;536(7616):344-34
Biro M, Maître JL, Dual pipette aspiration: a unique tool for studying intercellular adhesion. MethodsCellBiol. 2015;125:255-67
Porazinski S et al, YAP is essential for tissue tension to ensure vertebrate 3D body shape. Nature. 2015 May 14;521(7551):217-221
Maître JL et al, Pulsatile cell-autonomouscontractility drives compaction in the mouse embryo. Nat CellBiol. 2015 Jul;17(7):849-55
Maître JL et al, Adhesion functions in cell sorting by mechanically coupling the cortices of adhering cells. Science. 2012;338(6104):253-6